Our research has shown that the ingestion of fructose with fat exacerbates postchallenge lipidemia. Here, we investigated the effects of previous-day and pre- and postchallenge aerobic exercise on lipidemia induced by the co-ingestion of fructose and fat.

Methods: Healthy young Japanese women underwent four test trials in two experiments. In Experiment 1, we studied the effects of previous-day aerobic exercise (30-min treadmill walk, approx. 50%VO₂max) in four trials: (1) Ft trial, fat cream (0.35 g/kg body mass as fat), (2) FtE trial, fat cream + exercise, (3) FtFr trial, fat cream + fructose (0.5 g/kg), and (4) FtFrE trial, fat cream + fructose + exercise. In Experiment 2, we studied the effects of pre- vs. postchallenge exercise: (1) Ft trial, fat cream, (2) FtFr trial, fat cream + fructose, (3) FtFrE_pre trial, fat cream + fructose + exercise prior to ingestion, and (4) FtFrE_post trial, fat cream + fructose + exercise after ingestion. Blood was sampled at baseline and 0.5, 1, 2, 4, and 6 h after ingestion in all trials.

Results: In Experiment 1, the postchallenge lipidemia tended to be mitigated in the FtE trial compared to the Ft trial, but in the FtFrE trial, it was not different compared to the FtFr trial. In Experiment 2, the serum triglyceride concentration at 6 h tended to be lower in the FtFrE_post trial versus the FtFr trial. The apolipoprotein B100 value at 6 h was significantly higher than the fasting level in the FtFr and FtFrE_pre trials, but not in the Ft and FtFrE_post trials. The rise of apolipoprotein B48 tended to be suppressed in the FtFrE_pre and FtFrE_post trials compared to the Ft and FtFr trials.

Conclusion: These results demonstrate that even moderate aerobic exercise can mitigate postprandial lipidemia induced by the ingestion of fat cream. However, when fat was ingested with fructose, the effect of previous-day exercise was equivocal. Postchallenge exercise (but not prechallenge exercise) may inhibit the increase in serum triglyceride and improve the postchallenge hyperlipidemia induced by fructose.

fructose, exercise, triglyceride, women.

Received: November 8, 2021; Accepted: November 17, 2021; Published: November 25, 2021

How to cite this article: Chiharu Iijima, Kaori Kuzawa, Erika Mizutani and Michitaka Naito, Effects of pre- vs. postchallenge aerobic exercise on lipidemia induced by the ingestion of fructose with fat, in healthy young women, International Journal of Nutrition and Dietetics 8 (2022), 1-14. http://dx.doi.org/10.17654/2347527722001

This Open Access Article is Licensed under Creative Commons Attribution 4.0 International License

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