Non-inferiority tests for comparing two binomial proportions are frequently used in clinical trials to prove that a new drug with few side effects or low cost is not significantly inferior in efficacy to the standard drug. This article gives a brief summary of the statistical framework for assessing non-inferiority and presents some of the more popular non-inferiority tests. The main conclusion is that the Farrington-Manning test with continuity correction is the recommended non-inferiority test for comparing two binomial proportions.

non-inferiority tests, comparing proportions.