Variety of methods are available for analyzing repeated measurements data in clinical research. However, there is little information on how established methods, such as summary statistics approach,unstructured multivariate approach, profile analysis, and repeated measures ANOVA compare in practice. In this paper we compared the results by application to a clinical trial data set. The aim of this paper is to exemplify the use of these methods, and directly compare theirresults by application to a clinical trial data. The focus is on practical aspects rather than technical issues. The data considered were taken from a clinical trial on efficacy of Levocetrizine, Desloratidine and Fexofenadine in histamine induced wheal suppression at 1, 2 and 3 hours. The findings are presented and discussed.

clinical trials, repeated measurements.