The influences of nanoparticles as drug carriers on the walls of stenosed arteries are presented. In this study, three nanoparticles namely and Cu were used. It is observed that the addition of nanoparticles tends to reduce the resistance impedance of blood temperature in bell shaped stenosed arteries. The blood temperature increases slightly in the streamwise direction before the throat region. Thereafter, the blood temperature increases at a higher rate and reaches its maximum value at the stenosis throat. It is found that the temperature distribution is heavily dependent on parameters such as periodic body acceleration and Prandtl number.